Read e-book online A Symposium on Mechanisms of Toxicity PDF

By W. N. Aldridge (eds.)

ISBN-10: 1349010855

ISBN-13: 9781349010851

ISBN-10: 1349010871

ISBN-13: 9781349010875

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E-e, C-methionine sulphoximine, and then placed on a column of Sephadex G-50, a protein fraction was obtained which contained 14C (Fig. 9). About 8 mol of methionine sulphoximine were bound per mol of inactivated enzyme. When this experiment was carried out in the presence of 14 C-methionine sulphoximine and ATP labelled with 32P in the terminal two phosphoryl moieties, 2 mol of 32P were bound per mol of 14C bound. When the inactivated enzyme obtained by gel filtration was denatured by brief heating at 100°C (or when it was treated with perchloric acid) followed by centrifugation, all the radioactivity appeared in the protein-free supernatant solution.

Soc. exp. Bioi. , SPAAN, G. & KLUSSMANN, F. W. (1969). Pfliigers Arch. ges. , 312, 1 WERNER, G. & KUPERMAN, A. S. (1963). In Handbuch der Experimentellen Pharmakologie, vol. 15, ed. Koelle, G. , pp. 57Q-678. Berlin: Springer Verlag WoLTHUIS, 0. L. & MEETER, E. (1968). Eur. J. , 2, 387 ZETLER, G. (1968). Int. J. , 7, 325 STELTER, W. MECHANISM OF INHIBITION OF GLUTAMINE SYNTHETASE BY METHIONINE SULPHOXIMINE A. MEISTER, R. A. RONZIO, W. B. ROWE, J. D. GASS &S. L. N. RAO Department of Biochemistry, Cornell University Medical College, N.

Rowe, J. D. Gass, & S. L. N. Rao CAF} AMP H 8 0 4 1E c 14 14 ATP ·I e X {3·84 nmol ( 32 P) 434 nmol ( 14 C) 1- - 2 11- ·I ADP .... Origin M 4 I I 8 I 4·16nmol lr-f" 1 12 16 L I 20 I l I 24 em FIG. 10. Separation of radioactive compounds obtained after denaturation of the inhibited enzyme. A mixture (vol. /nmol phosphate), KCl (0·1 M), imidazole-HCl buffer, pH 7·2 (0·01 M), EDTA (0·1 mM) was incubated for 30 min at 37°C; enzymatic activity was completely inhibited. The solution was added to a column of Sephadex G-50 (0·8 x 18 em) previously equilibrated with NH 4 HC0 3 (pH 8·0; 0·05 M) and 0·1 mM EDTA.

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A Symposium on Mechanisms of Toxicity by W. N. Aldridge (eds.)


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